A cat named Tom’s owners move to a new house, but he is distracted by his pursuit of a mouse named Jerry and is left behind by the moving van. Tom chases the van, but is attacked by a bulldog and forced to hide in the empty house. The next morning, the house is demolished, leaving Tom and Jerry homeless and wandering the streets until they meet a stray dog named Puggsy and his flea companion, Frankie.
Upon introducing themselves, Tom and Jerry, discovering they can both speak, are persuaded to befriend each other to survive, but when Jerry accepts to be Tom’s friend, Tom disagrees, leaving Jerry to do the same. While Tom and Jerry search for food, Puggsy and Frankie are captured by dogcatchers, and when Tom is confronted by a hostile group of singing alley cats, Jerry traps them in a sewer. Tom and Jerry soon meet Robyn Starling, a young runaway girl whose widowed father was supposedly killed in an avalanche during an expedition in Tibet, while her mother had died when she was just a baby. Robyn and her family’s fortune were put in the custody of her wicked guardian “Aunt” Pristine Figg and her lawyer Lickboot, who see Robyn only as a means to keep their obtained wealth.
Figg reluctantly allows Tom and Jerry to stay, but the pair’s food fight with Figg’s morbidly obese skateboard-riding dachshund Ferdinand and their discovery of a telegram confirming the survival of Robyn’s father convinces Figg to send them to the sadistic animal trafficker Dr. Applecheek. His public persona as a kind animal lover allows Figg to falsely assure Robyn as she locks her in the attic to prevent her from learning of her father’s survival. Tom and Jerry reunite with Puggsy and Frankie, who suggest using a nearby control panel to release the cages, freeing all the captured animals. Tom and Jerry return to Robyn and inform her of her father’s survival. The three set out on a raft to find Robyn’s father, but the raft is suddenly struck and split by a ship and separating them.
Meanwhile, in Tibet, Robyn’s father is alerted of his daughter’s situation and flies back to America to find her. The next day, Figg and Lickboot place a bogus $1 million bounty on Robyn that they have no intent on paying. Robyn is found and hosted by amusement park manager Captain Kiddie and his parrot puppet Squawk. Kiddie and Squawk are initially accommodating to Robyn until they see Figg’s bounty on a milk carton, whereupon they detain Robyn on a Ferris wheel and contact Figg. Applecheek and his dogcatchers also learn of the bounty and attempt to collect it before Figg’s arrival. Tom and Jerry manage to find and rescue Robyn, trap the dogcatchers and escape in a paddle steamer with Figg, Lickboot, Ferdinand, Kiddie and Squawk, and Applecheek in hot pursuit.
Tom and Jerry barely manage to survive the cabin’s collapse. The pair begin a new life in Robyn’s luxurious villa and return to their old habits. Don’t miss the thrilling adventure of Tom and Jerry: The Movie online full movie!