In an unnamed New Mexico bordertown, nightclub promoter Jerry Manning hires a black leopard as a publicity stunt for his girlfriend, Kiki Walker, a performer there. Kiki uses the opportunity to upstage the act of her rival, Clo-Clo, by making an entrance into the nightclub with the leopard on a leash. Angered, Clo-Clo frightens the leopard with her castanets, causing it to escape into the night. Charlie, the Native American owner of the leopard, begins to demand money from Jerry to replace the cat.
That night, Teresa, a young local woman, encounters the leopard under a bridge and tragically loses her life. The medical examiner rules her death an accident caused by the leopard. Shortly after, another local, Consuelo, meets a similar fate at the hands of the leopard within the cemetery’s stone walls.
As more murders occur, suspicions arise within the town. Jerry questions the police about the leopard’s behavior, while Charlie himself becomes a suspect after being influenced by local rumors. Clo-Clo, warned by a fortune teller, meets a grim fate, leading to further chaos in the community.
Kiki and Jerry’s departure coincides with a chilling discovery about the leopard’s demise. With tensions rising, a shocking revelation unfolds as the true killer is unmasked during a haunting procession.
Amidst the aftermath, Jerry and Kiki find solace in each other’s love as they come to terms with the harrowing events that transpired. As the town tries to heal, the shadow of the Leopard Man’s legacy lingers, urging viewers to experience the spine-tingling tale in The Leopard Man Full Movie.