Andy, a 41-year-old virgin, lives with his friends Seth, Sanjay, Jonah, and Michael. Working as a part-time failed standup comedian with his friend Blaqguy, who has Benjamin Button’s Disease, Andy navigates life oblivious to advances from women.
During a night at the club, Andy meets Kim but their connection is cut short when she abruptly leaves behind her prosthetic leg. As his friends discover Andy’s virginity during a poker game, their misguided attempts to help him lose it only lead to comedic failures.
Sarah Marshall, taken by Andy’s awkward charm, tries to seduce him but he falters, regaining courage only to find Blaqguy, now in puberty, with Sarah. A messy confrontation leaves Andy covered in filth, and Sarah later claims to be pregnant with his child before leaving.
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Seeking solace, Andy heads to Hawaii where he reunites with Kim, now a hotel manager. Sarah and her new boyfriend stay nearby, leading to tense moments and failed attempts to provoke jealousy. As Andy reconciles with Kim, their wedding night takes an unexpected turn.
A subplot involving Jonah, Michael, and McAnalovin’ unfolds, filled with mischief and misadventures. Police encounters, mistaken identities, and encounters with vampires and unexpected allies add layers of chaos to the story.
Experience the hilarity, mishaps, and unexpected twists in this quirky movie that will keep you entertained from start to finish. Don’t miss out on the laughter and the wild ride of Andy and his friends’ escapades!