In 1971, 26-year-old Bob Hughes leads a nomadic group of drug addicts—his wife Dianne, his best friend Rick, and Rick’s teenage girlfriend Nadine—who travel across the Pacific Northwest robbing pharmacies and hospitals to support their habits. After stealing from a Portland, Oregon, pharmacy, they drive home to get high, and are visited by David, a local low-life seeking hard-to-find Dilaudid. Bob claims they have none, but offers to trade him morphine for speed.
Later, police officers led by Detective Gentry, who correctly assumes the group is responsible for the pharmacy robbery, raid and wreck their apartment in an unsuccessful search for the stolen drugs, which Dianne has buried outside. After moving to another apartment, Bob realizes that Gentry has the group under surveillance.
Bob proceeds to devise an elaborate ruse which results in one of the policemen, Trousinski, being mistaken for a peeper by a neighbor who shoots and injures him. The group goes “crossroading” and robs a drugstore, finding vials of pure powdered Dilaudid worth thousands of dollars each. Bob convinces Dianne that he should rob a hospital to continue their streak of luck.
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During the hospital robbery, Bob is almost captured, and the group returns to their motel to find Nadine has fatally overdosed on a bottle of Dilaudid. Bob, haunted by the events, decides to get clean and begin a 21-day methadone treatment program. However, Dianne refuses to join him, leading to their eventual separation.
Bob moves into a long-stay motel in Portland and encounters an elderly drug-addicted priest named Tom at the methadone clinic. Gentry warns Bob of impending threats from Trousinski and encourages him to stay sober. Bob’s encounter with David, witnessing bullying and violence, further solidifies his resolve to change his lifestyle.
One night, Dianne arrives at the motel with Rick, now the group’s new leader. Bob recounts his journey to redemption, driven by Nadine’s death and the realization of his impending fate. After a violent encounter with David, Bob is shot and taken to the hospital. As he reflects on his life choices, Bob faces the irony of his situation, highlighting the cycle of addiction and redemption.
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