Schoolteacher and family man Ed Avery has been suffering bouts of severe pain and even blackouts. His strange illness begins to concern his wife Lou. After he collapses at home one night, Ed is hospitalized. When a cab driver visits Ed, Lou—who suspected him of being unfaithful—learns that he works part-time as a dispatcher to help pay their bills. They kiss, and when the doctors expect Lou to leave the room, Ed declares that there are no more secrets.
The diagnosis is polyarteritis nodosa, a rare inflammation of the arteries. It is estimated that Ed has only months to live. He agrees to experimental treatments with cortisone, a corticosteroid.
Ed makes a remarkable recovery and begins to spend more time with Lou and their young son Richie. However, shortly after beginning his cortisone regimen, Ed begins to abuse the medication. He is subject to turbulent mood swings and begins to lie to his doctor to obtain more.
Although Ed has taken a sabbatical from his teaching position, he remains on the local Parent–Teacher Association board. At one of their meetings, Ed blatantly insults a mother about her child’s intelligence, and seems unbothered when his colleague Wally Gibbs informs him that the woman is the association president.
Wally stops at the Avery home and informs Lou of Ed’s extravagant and abrasive behavior. Ed returns in the midst of the conversation and makes a snide remark, implying that Wally is attracted to Lou.
When Wally leaves, Ed insults Lou, deeming her to be intellectually inferior to him and unworthy of their marriage. After consuming another full prescription of cortisone, Ed impersonates a doctor and forges a new prescription at the local pharmacy. While playing football with Richie, Ed grows disproportionately aggressive, pushing the child beyond his limits. The incident disturbs Lou, who observes it from the kitchen window.
Wally confronts Lou with research suggesting that cortisone can trigger psychosis in some patients when taken in high doses (known colloquially as “‘roid rage”). Ed’s mental state further declines, and he continually insults those around him, expressing abject arrogance, grandiosity and anger over minor inconveniences.
When Lou attempts to inform Ed that the cortisone may be negatively affecting him, Ed reminds her that his polyarteritis will recur without it, and that he will not survive. That night, Ed forces Richie to stay up late into the night to study mathematics, and verbally abuses the child when he is unable to solve certain problems. At dinner, Ed announces he wishes to divorce Lou.
The following day, a desperate Richie raids Ed’s medicine cabinet, hoping to steal his father’s cortisone pills and dispose of them. When Ed corners Richie in his bedroom, Lou phones Wally for help. To chastise Richie, Ed reads a passage from the Bible recounting the binding of Isaac.
When Lou pleads with Ed, he states that he plans to carry out a murder–suicide, killing her and Richie before ending his own life. In a rage, Ed locks Lou in a coat closet, blares the volume on the family’s television set, and goes to Richie’s bedroom armed with a blade from a pair of scissors.
When Ed arrives at Richie’s bedroom, he begins to hallucinate, and Richie flees downstairs just as Wally bursts into the house. In a scuffle, Wally manages to beat Ed unconscious. Ed is subsequently hospitalized and heavily sedated.
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His doctor, Dr. Norton, informs Lou that the cortisone may have resulted in irreversible brain damage, and that he may never return to his prior mental state. Despite this, Ed will still require strictly-meted doses of the cortisone to survive. Norton states that, should Ed be able to recall the events of the previous weeks, he may have a chance of mental recovery.
Lou and Richie visit Ed in his hospital room. Ed awakens and, although disoriented, soon recognizes them. Ed, fully able to recall the events, embraces his wife and son. Experience the emotional journey of “Bigger Than Life” for free and witness the turmoil and redemption that unfolds in this gripping tale.