While hunting in the jungle of Cameroon, Scott Cowley and his guide receive radio contact from Scott’s brother, Charlie, that his own guide is missing. The call is interrupted by horrific sounds suggesting an animal attack, and the pair set out to help, only to fall prey themselves. Charlie finds Scott fatally wounded.
Seven years later, Charlie’s nephew, Derek, lives with his mother Gwen and his emotionally abusive stepfather, Mitch. Derek prepares to take advantage of Mitch’s planned work trip to use his cabin for a weekend party with classmates he hopes to impress. That night, the cabin is attacked by a werewolf. The werewolf brutally murders four of the partygoers. Only Derek and Sam manage to escape.
Fearing the truth is too unbelievable, the pair of survivors allege they didn’t see the attacker. Mitch picks Derek up from the police station and tells him his actions make him responsible for the massacre. Sam and Derek suspect that Mitch is the werewolf and attempt to piece together proof, as tensions rise in the household.
When Charlie pays a surprise visit, Derek and Sam confide in him and are surprised to find he believes them. Charlie explains that he believed the werewolf in Cameroon to be Mitch, as Mitch had an obsession with Gwen. Charlie cautions the teens that an accusation cannot be made without DNA evidence to compare to a hair sample he kept from the werewolf. Meanwhile, Charlie reconnects with Gwen, and romance is likewise budding between Sam and Derek.
Derek later finds the DNA report and steps up to confront Mitch about Charlie’s death. Derek’s mother also decides to leave Mitch. In retaliation, Mitch kidnaps Sam and demands Derek meet him in the cabin alone. Derek arrives to find another group of youths eager to explore the site, which is now locally notorious as the scene of a massacre. Mitch transforms and attacks them one by one until only Derek and Sam remain. They fight Mitch with silver weapons and eventually set him on fire, also burning down the cabin in the process. After escaping, Derek and Sam embrace, but Mitch has survived long enough for a final attack on his stepson. As Mitch dies, he tells Derek the curse is now his. Sam assuages Derek’s fears with a promise to stick by him whatever happens, and they drive off together on her moped.
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